IndraLab

Statements

ASF1A activates PAN2. 3 / 3
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"Indeed, USP52 deficiency impaired chromatin assembly and DNA replication as well as S-phase progression, the effect of which could be largely restored by ASF1A gain of function."
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"Meanwhile, western blotting analysis revealed that the upregulation of H3K56Ac trigged by IR was disrupted upon USP52 depletion, the effect of which could be restored by ASF1A gain of function."
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"Taken together, these data indicate that USP52 targets ASF1A and K129 for deubiquitination and USP52 is a bona fide deubiquitinase for ASF1A."
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