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YOD1 inhibits ZNF24. 4 / 4
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"Additionally, the destabilization of the ZNF24 protein induced by YOD1 suppression was shown to be dependent on proteasome and was abolished following treatment with MG132, a proteasome inhibitor (Fig. 6E, F)."
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"Notably, in protein half-life experiments, overexpression of wild-type YOD1 significantly slowed the degradation of ZNF24 compared to the control group, whereas ZNF24 degradation in the YOD1-C160S overexpression group was similar to that of the control (Fig. 6G, H)."
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"Our findings indicated that YOD1 knockdown in ccRCC cells decreased the protein stability of ZNF24, leading to attenuated transcriptional repression of VEGFA, which resulted in increased VEGFA expression and promoted angiogenesis."
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"The deubiquitinase YOD1 suppresses tumor progression by stabilizing ZNF24 in clear cell renal carcinoma."
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