IndraLab

Statements

PLAGL2 increases the amount of USP37. 8 / 8
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"PLAGL2 activated the transcription of deubiquitinase USP37, which then interacted with and deubiquitinated Snail1 protein directly."
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"Finally, PLAGL2 modulates SNAI1 stability by activating USP37 transcription."
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"Besides, we showed that PLAGL2 directly activates USP37 expression, which targets Snail1 to proteasome ubiquitination degradation."
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"Studies have shown that PLAGL2 can activate the transcription of the deubiquitinating enzyme USP37 that deubiquitinates and stabilizes Snail family transcriptional repressor 1 (Snail1), finally fostering Snail1-mediated cell proliferation [62]."
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"PLAGL2 modulates Snail1 stability by activating USP37 transcription."
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"These results collectively suggest that PLAGL2 transcriptionally activates USP37 expression to increase Snail1 protein levels, which in turn mediates the proliferation, migration, and invasion of GC cells."
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"Moreover, silencing PLAGL2 decreased the mRNA level of USP37 in SGC7901 cells, whereas PLAGL2 overexpression increased the USP37 mRNA level in AGS cells."
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"Wu et al. [25] also found that PLAGL2 could activate USP37 expression and stabilize Snail1 to promote the proliferation and migration of gastric cancer cells."
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