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PSMD14 activates proteolysis. 3 / 3
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"Koulich et al. recently demonstrated that siRNA interference of PSMD14 remarkably decreased cellular proteasome activity via disrupted 26S proteasome assembly and inhibited cellular protein degradatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"RPN11 inhibition prevents the proteolysis of a subset of polyubiquitinated protein substrates and is emerging as a new proteosome-targeting therapy against breast cancer by perturbing protein homeostasis 34, 35 ."
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"Failure of RPN11 to remove the polyubiquitin chain results in steric hindrance of the substrate into the 20S core particle and thus prevents protein degradation, making RPN11 essential to the ubiquitin-proteasome system (UPS) (88)."
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