IndraLab

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Ethanol inhibits NLRP3. 26 / 26
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"Also lending credibility to the hypothesis that ethanol inhibits apical events in Nlrp3 inflammasome activation is our finding that the alcohol can reduce IL-1beta secretion when given up to 15 minutes after stimulation with ATP (XREF_FIG)."
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"10 We showed earlier that an ethanol extract of A. cinnamomea suppresses NLRP3 inflammasome activation and secretion of pro inflammatory IL-1beta and IL-18 in macrophages."
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"There is some literature to suggest that low doses of ethanol can inhibit the formation of ROS via inhibition of NLR Family Pyrin Domain Containing 3 (NLRP3) protein."
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"We report here that acute ethanol administration can override the effects of chronic ethanol and inhibit NLRP3 inflammasome activation (XREF_FIG), helping to explain why alcoholics who have a background of chronic inflammatory symptoms still experience transient immunosuppression after binge drinking."
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"Consistent with ethanol 's inability to inhibit the Nlrp1b inflammasome, this demonstrates that ethanol does act to prevent NLRP3 inflammasome activation at the level of ASC speck formation."
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"Recently, Hoyt et al. reported that acute ethanol administration dose dependently -- as discussed before -- inhibited the activation of the NLRP3 inflammasome, addressing the impact of alcohol on the stimulation of the protein tyrosine phosphatase [XREF_BIBR]."
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"Some evidence on the conflicting effects of ethanol on NLRP3 inflammasome activation has been presented : Ethanol markedly attenuated activation of the NLRP3 inflammasome in response to diverse danger signals, including ATP and nigericin, in lipopolysaccharide (LPS)-primed macrophages."
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"It has been shown that ethanol blocks the NLRP3 inflammasome activation in several cell types, including human peripheral blood mononuclear cells, murine bone marrow derived dendritic cells and neutrophils."
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"Studies with NLRP-3 knockout mice show that alcohol-induced liver inflammation and fibrosis were attenuated in the absence of NLRP3 (86, 278)."
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"We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished ASC speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow derived dendritic cells, mouse neutrophils, and human PBMCs."
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"In addition to its direct toxicity, ethanol has two contrasting effects on the immune system : the nucleotide oligomerization domain like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure."
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"This indicates that ethanol does not inhibit the Nlrp3 inflammasome by blocking potassium efflux from stimulated cells, and is likely acting downstream of this critical point."
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"A mitochondrion-targeted antioxidant Mito-TEMPO abrogates mtROS release and reduces the upregulation of IL-1β and IL-18 induced by ethanol, effectively inhibiting NLRP3 activation [31]."
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"42 Whether low doses of ethanol inhibit NLRP3, reducing ROS in PC12 cells will need to be examined in the future."
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"Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation."
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"The NLRP3 inflammasome, a multi protein intracellular pattern recognition receptor complex that facilitates the cleavage and secretion of the pro inflammatory cytokines IL-1beta and IL-18, can be inhibited by ethanol and we sought to better understand the mechanism through which this occurs and whether chemically similar molecules exert comparable effects."
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"Ethanol inhibits activation of NLRP3 and AIM2 inflammasomes in human macrophages -- a novel anti-inflammatory action of alcohol."
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"Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation."
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"In contrast, co-administration of folecitin (30 mg/kg body weight) reduced ethanol-induced oxidative stress, inhibited p-JNK, and deactivated the NLRP3-inflammasome complex."
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"Our results demonstrate that ethanol antagonizes the NLRP3 inflammasome at an apical event in its activation through the stimulation of protein tyrosine phosphatases, an effect shared by other short-chain alcohols."
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"Ethanol inhibited the activation of the NLRP3 inflammasome by cholesterol crystals, SAA, ATP, and nigericin over a wide range of concentrations (2.5/1000-20/1000 corresponding to 43 mM-343 mM)."
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"Ethanol blocks NLRP3 inflammasome activation in several cell types."
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"Correspondingly, ethanol induced NLRP3 inflammasome activation was decreased in cells treated with HIF-1alpha inhibitor CAY10585."
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"Ethanol treatment at each time point before ATP addition and up to 15 minutes after stimulation was found to inhibit Nlrp3 inflammasome activation, and consistent with previous experiments, ethanol treatment had no impact on macrophage priming and TNF production (XREF_FIG)."
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"These results mean that in both mouse and human cells, and in multiple cell types, ethanol is able to inhibit NLRP3 activation and IL-1beta production."
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"The ethanol extract of flower buds of Tussilago farfara L. attenuates cigarette smoke-induced lung inflammation through regulating NLRP3 inflammasome, Nrf2, and NF-κB."
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