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Ethanol inhibits NLRP3. 33 / 33
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"Our previous work showed that an ethanol extract of A. cinnamomea mycelium inhibits the NLRP3 inflammasome and secretion of pro-inflammatory cytokines (interleukin-1β, interleukin-18 and tumor necrosi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Silence of endogenous TXNIP expression blocked those events, as well as hepatic injuries including apoptosis and oxidative stress, confirming the essential role of TXNIP in the induction of NLRP3 infl[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We conclude that impaired Rab11b could alleviate alcohol-induced liver injury via autophagy-mediated NLRP3 degradation."
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"Also lending credibility to the hypothesis that ethanol inhibits apical events in Nlrp3 inflammasome activation is our finding that the alcohol can reduce IL-1beta secretion when given up to 15 minutes after stimulation with ATP (XREF_FIG)."
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"Recently, Hoyt et al. reported that acute ethanol administration dose dependently -- as discussed before -- inhibited the activation of the NLRP3 inflammasome, addressing the impact of alcohol on the stimulation of the protein tyrosine phosphatase [XREF_BIBR]."
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"It has been shown that ethanol blocks the NLRP3 inflammasome activation in several cell types, including human peripheral blood mononuclear cells, murine bone marrow derived dendritic cells and neutrophils."
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"Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation."
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"Ethanol and Other Short-Chain Alcohols Inhibit NLRP3 Inflammasome Activation through Protein Tyrosine Phosphatase Stimulation."
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"The NLRP3 inflammasome, a multi protein intracellular pattern recognition receptor complex that facilitates the cleavage and secretion of the pro inflammatory cytokines IL-1beta and IL-18, can be inhibited by ethanol and we sought to better understand the mechanism through which this occurs and whether chemically similar molecules exert comparable effects."
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"We show that ethanol can specifically inhibit activation of the NLRP3 inflammasome, resulting in attenuated IL-1beta and caspase-1 cleavage and secretion, as well as diminished ASC speck formation, without affecting potassium efflux, in a mouse macrophage cell line (J774), mouse bone marrow derived dendritic cells, mouse neutrophils, and human PBMCs."
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"Our results demonstrate that ethanol antagonizes the NLRP3 inflammasome at an apical event in its activation through the stimulation of protein tyrosine phosphatases, an effect shared by other short-chain alcohols."
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"The results reported here are important because, in combination with evidence that LUX inhibits TLR signaling and activation of the NLRP3 inflammasome at concentrations well below those attained in patients, they indicate that LUX as a unique kinase profile quite different from that of IB and suggest that LUX may have activity against autoimmune and inflammatory diseases of multiple types in addition to lymphomas."
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"They suggest that the impact of alcohol consumption on this pathway is that it increases the turnover of Apo A-I and A-II, leading to increased mobilization of tissue cholesterol and increased HDL-C l[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Ethanol treatment at each time point before ATP addition and up to 15 minutes after stimulation was found to inhibit Nlrp3 inflammasome activation, and consistent with previous experiments, ethanol treatment had no impact on macrophage priming and TNF production (XREF_FIG)."
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"We speculate that the ethanol extract of PEL may inhibit the activation of NLRP3 by scavenging ROS."
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"This indicates that ethanol does not inhibit the Nlrp3 inflammasome by blocking potassium efflux from stimulated cells, and is likely acting downstream of this critical point."
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"Ethanol blocks NLRP3 inflammasome activation in several cell types."
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"There is some literature to suggest that low doses of ethanol can inhibit the formation of ROS via inhibition of NLR Family Pyrin Domain Containing 3 (NLRP3) protein."
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"42 Whether low doses of ethanol inhibit NLRP3, reducing ROS in PC12 cells will need to be examined in the future."
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"10 We showed earlier that an ethanol extract of A. cinnamomea suppresses NLRP3 inflammasome activation and secretion of pro inflammatory IL-1beta and IL-18 in macrophages."
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"Correspondingly, ethanol induced NLRP3 inflammasome activation was decreased in cells treated with HIF-1alpha inhibitor CAY10585."
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"AMPK inactivation curbs ELG inhibiting ethanol-triggered NLRP3 signaling and damage in hepatocytes."
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"Studies with NLRP-3 knockout mice show that alcohol-induced liver inflammation and fibrosis were attenuated in the absence of NLRP3 (86, 278)."
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"In contrast, co-administration of folecitin (30 mg/kg body weight) reduced ethanol-induced oxidative stress, inhibited p-JNK, and deactivated the NLRP3-inflammasome complex."
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"Additionally, this study revealed that the 70% ethanol extract of C. spicatus could significantly inhibit the activation of the NLRP3 pathway and TLR4/MYD88 pathway in the kidney of HN mice, and suppress the protein expression of nuclear transcription factor NF-κB."
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"In addition to its direct toxicity, ethanol has two contrasting effects on the immune system : the nucleotide oligomerization domain like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure."
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"Makauy leaf ethanol extract inhibits the NLRP3 inflammasome."
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"Some evidence on the conflicting effects of ethanol on NLRP3 inflammasome activation has been presented : Ethanol markedly attenuated activation of the NLRP3 inflammasome in response to diverse danger signals, including ATP and nigericin, in lipopolysaccharide (LPS)-primed macrophages."
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"Ethanol inhibited the activation of the NLRP3 inflammasome by cholesterol crystals, SAA, ATP, and nigericin over a wide range of concentrations (2.5/1000-20/1000 corresponding to 43 mM-343 mM)."
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"A mitochondrion-targeted antioxidant Mito-TEMPO abrogates mtROS release and reduces the upregulation of IL-1β and IL-18 induced by ethanol, effectively inhibiting NLRP3 activation [31]."
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"These results mean that in both mouse and human cells, and in multiple cell types, ethanol is able to inhibit NLRP3 activation and IL-1beta production."
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"Consistent with ethanol 's inability to inhibit the Nlrp1b inflammasome, this demonstrates that ethanol does act to prevent NLRP3 inflammasome activation at the level of ASC speck formation."
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"We report here that acute ethanol administration can override the effects of chronic ethanol and inhibit NLRP3 inflammasome activation (XREF_FIG), helping to explain why alcoholics who have a background of chronic inflammatory symptoms still experience transient immunosuppression after binge drinking."
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