IndraLab

Statements

USP10 activates Neoplasm Invasiveness. 17 / 17
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"Depleting USP10 significantly inhibited clonal growth potential and cellular invasion of pancreatic cancer cells."
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"Simultaneously, upregulation of USP10 in MG‐63 and Saos‐2 cells increased their migration and invasiveness abilities (Figure 2D,F)."
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"Thus, silencing USP10 inhibits clonal growth and invasion in pancreatic cancer cell lines, two pivotal hallmarks of cancer progression."
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"USP10 overexpression enhanced the viability, colony formation, migration and invasion of THCA cells."
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"Recently, Li et al. reported that CircCOL1A2 downregulates the ubiquitination level of RFC2 by upregulating the expression of USP10, promoting the invasion and migration of GC cells [10]."
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"We show that USP10 depletion inhibited cellular invasion in PDAC cells and decreased clonogenic ability, suggesting that silencing USP10 may decrease metastatic potential of pancreatic cancer.USP10 has been shown to be important for deubiquitinating ribosomal proteins i.e RPS2, RPS3, RPS10 to facilitate recycling and prevent degradation of ribosomal subunits ."
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"Furthermore, Yang et al. reported that USP10 promoted HCC cell migration and invasion by stabilizing the Smad4 protein ."
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"USP10 knockdown significantly suppressed cell invasion, which was rescued by EIF4G1 overexpression (Fig. 6A)."
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"Overexpression of USP10 significantly promoted cell invasion (Fig. 6B)."
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"In addition to USP10 controlling cell proliferation, a study from the Ouchida group revealed that USP10 promotes tumor migration or invasion."
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"We first found that USP10 knockdown remarkably inhibited HNSCC cell migration and invasion (Fig. S2A, B)."
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"Among these DUBs, OTUB1, and USP10 significantly enhanced cell proliferation and invasion (Figure 2A,B, Figure S2A)."
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"USP10 promotes cell proliferation, migration, and invasion in NSCLC through deubiquitination and stabilization of EIF4G1."
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"Collectively, this ample of evidence suggests that USP10 knockdown‐mediated YAP1 suppression potentially leads to increased expression of immunosuppressive molecules, such as PD‐L1, Galectin‐9, and M2 macrophages.3.4 Knockdown of USP10 reduces growth and invasiveness of pancreatic adenocarcinoma cells in vitro."
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"USP10 knockdown decreased the proliferation, migration, and invasion in NSCLC cells, which were rescued by EIF4G1overexpression."
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"In the present study, the experimental results obtained from in vitro cell models showed that downregulated USP10 significantly promoted GC cell migration and invasion, while upregulated USP10 significantly inhibited GC cell migration and invasion."
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"In the current study, we found that there was no correlation between expression of TM4SF1 and USP10, S100A12, p53, or Ki67 expression in GC, suggesting that TM4SF1 plays a distinct role in GC invasion and metastasis from those of USP10, S100A12, p53, or Ki67, although they all contribute to cancer invasion and metastasis."
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