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OTUB1 activates UBE2D1. 2 / 2
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"Notably, we demonstrate that S-glutathionylation of C23 or C204 of OTUB1 promotes binding of the E2-conjugating enzyme UBCH5A, leading to stabilization of SCL7A11 and augmentation of GSH in a GLRX-reversible manner."
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"Monoubiquitination of OTUB1 increases the interaction with UbcH5, resulting in a suppression of UbcH5 activity ( Li et al., 2014b )."
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