IndraLab

Statements

USP26 activates cell differentiation. 7 / 7
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"Conversely, lesser extent of CBX7 protein binding to the promoters of Cbx4 and Cbx6 is observed during Usp26 mediated ESC differentiation and RA induced ESC differentiation."
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"Correlative with the Oct4 gene expression data, occupancy at the Oct4 promoter by USP26, CBX4, CBX6, and H2A-ubi1 was low even during USP26 mediated ESC differentiation."
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"These results suggest that USP26 expression promotes ESC differentiation."
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"USP26 expression promotes ESC differentiation."
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"Furthermore, infection of ESCs with GFP tagged mouse (m) USP26 led to ESC differentiation in an RA independent manner."
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"Using screening of shRNA specific for the DUB subfamily USPs, we identified a novel cellular reprogramming repressor gene Usp26, which blocked somatic cell reprogramming into iPSCs and promoted differentiation by stabilizing PRC1 complexes."
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"We also found significant decrease in the gene expression of Cbx7, a Polycomb protein, upon Usp26 induced ESC differentiation."
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