IndraLab

Statements

Wild-type CSPalpha decreases the amount of KCNMA1. 4 / 4
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"These findings thus demonstrate that wild-type CSPalpha is able to restrict neuronal BK channel expression, and further help to explain why loss of CSPalpha function, due to genetic mutations, lead to elevated BK density in the CNS."
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"These data thus provide evidence that wild-type CSPalpha normally acts to restrict neuronal BK channel expression."
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"This observation raised the possibility that wild-type CSPalpha normally functions to limit neuronal BK channel expression."
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"Our earlier results reporting that loss and disruption of CSPalpha activity in either a knockout mouse or a neuronal cell line markedly increase BK channel expression XREF_BIBR indirectly suggested that in the CNS, wild-type CSPalpha may function to limit cellular BK channel expression."
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