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KCNH2 activates apoptotic process. 32 / 35
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"28 In ovarian cancer, exogenous of miR-493 expression promotes cellular apoptosis, resulting in breakdown of mitochondrial membrane potential and the activation of Caspases resulting in the fragmentation of DNA.29 All these findings indicate the roles of miR-493 in carcinogenesis and cancer progression and suggest that miR-493 may present a path to novel therapeutic strategies for managing patients with these specific cancer types.Several genes, including RhoC,16 IRS4,17 ANTXR1,18 RSPO2,18 hERG1,19 FZD427 and E2F1,28 have been previously identified as direct targets of miR-493."
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"16 NO. 3 Zheng et al. hERG1 Kz channels mediate positive regulation of SDF-1a-induced proliferationDownloaded by [University of Wisconsin - Madison] at 19:22 12 December 2017Figure 4 hERG1 Kz channels mediated SDF-1a-induced apoptosis in AML patients ' derived mononuclear cells."
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"The knockdown of hERG1 in HCT116 cells by siRNA, resulted in a significant decrease in Cla-mediated induction of cytotoxicity (Fig. 6a) and apoptotic cell death in HCT116 cells (Figs."
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"From this, it seems that hERG1 Kz is involved in SDF-1-induced apoptosis and hERG1 Kz channels promote AML-cell apoptosis activating different potential signaling pathways; further work is required to confirm the mechanism.Aberrant cell signaling is thought to play a role in maintenance of the leukemic clone in AML."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR In our experimental conditions, hyperstimulation of the hERG1 channel did not induce apoptosis after arresting the cells in the G0/G1 phase."
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"RNA interference of hERG also modulated HTC/3 cell apoptosis, since a 72-hour treatment of nano-siRNA significantly increased the portion of early apoptosis cells (annexin V +/PI-) versus the control (15.5% +/- 0.8% versus 3.2% +/- 0.3%, P < 0.01, XREF_FIG)."
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"Thus, B-RAF-sensitive hERG K + channel up-regulation possibly contributes to cell proliferation and apoptosis of tumor cells."
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"The upper-right quadrant indicated cell apoptosis.Figure 3 hERG1 Kz channels mediated SDF-1a-induced apoptosis in leukemic cell line."
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"Knockdown of hERG1 significantly suppressed cellular proliferation and invasion, and induced apoptosis, while inhibition of hERG1 significantly decreased activation of NF-kappaB."
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"Also, Staudacher et al. found that the hERG1 small molecule ligand doxazosin induces the apoptosis of glioblastoma cells XREF_BIBR."
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"Furthermore, specific siRNA mediated knock down of hERG expression triggered apoptosis, confirming the mechanistic role of small molecule induced hERG protein suppression."
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"XREF_BIBR By the silencing method, we found that downregulation of hERG caused cell death and apoptosis in HTC/3 cells."
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"The human ether-a-go-go related gene (HERG) that encodes a delayed rectifier K + channel was shown to promote H 2 O 2 -induced apoptosis in a variety of tumor cells expressing this channel, in direct [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Defect of Kcnh2 (Kcnh2 +/-) significantly aggravated septic cardiac dysfunction, exacerbated tissue damage and increased apoptosis under LPS challenge."
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"15 However, no evidence is available how Kcnh2 modulates sepsis related apoptosis in heart."
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"In addition, multiple studies have reported that the hERG channel mutation can induce cell apoptosis, not only in heart biopsies from patients, but also in studies in vitro (8,9,10)."
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"Therefore, it was hypothesized that the hERG missense mutation, L539fs/47-hERG, also causes cell apoptosis."
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"The study indicated that siRNA was successfully transferred to the target cells and knocked down hERG that inhibited cell growth and induced apoptosis in ATC cells in vitro."
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"For instance, simultaneous activation of KCa3.1 and inhibition of K v 11.1 with riluzole has been shown to synergistically increase apoptosis and overcome cisplatin resistance [115] ."
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"We hypothesized that pharmacological targeting of hERG protein would inhibit tumor growth by inducing apoptosis of GB cells."
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"Therefore, to identify other mechanisms involved in hERG mutation-induced cell apoptosis, an LQTS type 2 transgenic animal is to be used in future investigations.In conclusion, the present study is the first, to the best of our knowledge, to investigate the mechanisms of cardiomyo-cyte apoptosis caused by hERG channel mutations."
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"Here, we show that HERG conductance markedly promotes H2O2 induced apoptosis of various tumor cells, whereas HERG expression facilitates the tumor cell proliferation caused by tumor necrosis factor (TNF) ligand (TNF-alpha)."
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"37 Cell type- and environment specific effects on apoptosis are suggested by reports of hERG activity promoting apoptosis."
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"XREF_FIG - XREF_FIG, hERG1 downregulation and/or inhibition prevented proliferation and invasion, and induced apoptosis of osteosarcoma cells."
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"HERG potassium channels, previously recognized to regulate cardiac action potential repolarization, modulate GB cell apoptosis."
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"The small molecule hERG ligand doxazosin induced concentration dependent apoptosis of human LNT-229 (EC 50 = 35 microM) and U87MG (EC 50 = 29 microM) GB cells, accompanied by cell cycle arrest in the G0/G1 phase."
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"SiRNA Inactivation of hERG K + Channels Triggers Apoptosis of GB Cells."
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"Silencing HERG inhibited the apoptosis induced by cisplatin both in vitro and in vivo, by attenuating the cisplatin effects on Bcl-2, Bax and active caspase-3."
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"Another in vitro and in vivo experiment on the CRC model, clarithromycin, an antibiotic targeting Kv11.1, induced apoptosis and increased the cytotoxic effect of 5-fluorouracil (78)."
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"The results indicate that hERG1 Kz channels promote apoptotic cell death, while SDF-1a can protect leukemic cell apoptosis."
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"Finally, Kv11.1, also named hERG (human ether-a-go-go related gene) and known to be abundantly expressed in a variety of tumor cells, has been proposed to mediate H 2 O 2 -induced apoptosis in various[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"HERG K channel conductance promotes H2O2 induced apoptosis in HEK293 cells : cellular mechanisms."
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