IndraLab

Statements

KCNH2 activates apoptotic process. 20 / 22
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"SiRNA Inactivation of hERG K + Channels Triggers Apoptosis of GB Cells."
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"37 Cell type- and environment specific effects on apoptosis are suggested by reports of hERG activity promoting apoptosis."
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"Also, Staudacher et al. found that the hERG1 small molecule ligand doxazosin induces the apoptosis of glioblastoma cells XREF_BIBR."
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"XREF_FIG - XREF_FIG, hERG1 downregulation and/or inhibition prevented proliferation and invasion, and induced apoptosis of osteosarcoma cells."
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"Here, we show that HERG conductance markedly promotes H2O2 induced apoptosis of various tumor cells, whereas HERG expression facilitates the tumor cell proliferation caused by tumor necrosis factor (TNF) ligand (TNF-alpha)."
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"We hypothesized that pharmacological targeting of hERG protein would inhibit tumor growth by inducing apoptosis of GB cells."
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"XREF_BIBR By the silencing method, we found that downregulation of hERG caused cell death and apoptosis in HTC/3 cells."
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"The small molecule hERG ligand doxazosin induced concentration dependent apoptosis of human LNT-229 (EC 50 = 35 microM) and U87MG (EC 50 = 29 microM) GB cells, accompanied by cell cycle arrest in the G0/G1 phase."
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"HERG potassium channels, previously recognized to regulate cardiac action potential repolarization, modulate GB cell apoptosis."
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"RNA interference of hERG also modulated HTC/3 cell apoptosis, since a 72-hour treatment of nano-siRNA significantly increased the portion of early apoptosis cells (annexin V +/PI-) versus the control (15.5% +/- 0.8% versus 3.2% +/- 0.3%, P < 0.01, XREF_FIG)."
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"The study indicated that siRNA was successfully transferred to the target cells and knocked down hERG that inhibited cell growth and induced apoptosis in ATC cells in vitro."
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"The knockdown of hERG1 in HCT116 cells by siRNA, resulted in a significant decrease in Cla-mediated induction of cytotoxicity (Fig. 6a) and apoptotic cell death in HCT116 cells (Figs."
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"Silencing HERG inhibited the apoptosis induced by cisplatin both in vitro and in vivo, by attenuating the cisplatin effects on Bcl-2, Bax and active caspase-3."
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"15 However, no evidence is available how Kcnh2 modulates sepsis related apoptosis in heart."
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"XREF_BIBR, XREF_BIBR, XREF_BIBR In our experimental conditions, hyperstimulation of the hERG1 channel did not induce apoptosis after arresting the cells in the G0/G1 phase."
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"HERG K channel conductance promotes H2O2 induced apoptosis in HEK293 cells : cellular mechanisms."
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"Defect of Kcnh2 (Kcnh2 +/-) significantly aggravated septic cardiac dysfunction, exacerbated tissue damage and increased apoptosis under LPS challenge."
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"Knockdown of hERG1 significantly suppressed cellular proliferation and invasion, and induced apoptosis, while inhibition of hERG1 significantly decreased activation of NF-kappaB."
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"Furthermore, specific siRNA mediated knock down of hERG expression triggered apoptosis, confirming the mechanistic role of small molecule induced hERG protein suppression."
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"Thus, B-RAF-sensitive hERG K + channel up-regulation possibly contributes to cell proliferation and apoptosis of tumor cells."
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