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Quercetin inhibits EIF2AK1. 6 / 6
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"We found that similar to human and mouse HRI, canine HRI kinase was inhibited with IC 50 values equal to ~ 1 muM by quercetin, demonstrating that among mammalian HRI, ATP binding and catalysis are conserved."
19946423
sparser
"In this study, we show that inhibition of HRI by quercetin is able to increase de novo protein translation in canine reticulocytes ( xref ) and also in mouse and rat reticulocytes (data not shown)."
19946423
reach
"In this study, we show that inhibition of HRI by quercetin is able to increase de novo protein translation in canine reticulocytes (XREF_FIG) and also in mouse and rat reticulocytes (data not shown)."
19946423
sparser
"To determine the effect of HRI inhibition by quercetin on protein synthesis, we treated canine blood with either 1 or 10 μ M quercetin for 4 hours in the presence of [ 35 S]-methionine ( xref )."
19946423
reach
"Quercetin, a kinase inhibitor known to inhibit mouse and human HRI, inhibits canine HRI in a concentration dependent manner."
19946423
sparser
"In addition, it has been reported that HRI is inhibited by quercetin, a pan-kinase ATP-competitive inhibitor ( xref , xref )."
36063997