IndraLab

Statements

TLR4 binds SIRPA. 5 / 5
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"In addition, CD47 is the ligand of SIRPA, and CD47/SIRPA interaction is the major determinant of escape from phagocyte-mediated cell clearance. xref In our study, we demonstrated that SIRPA physically interacted with TLR4; therefore, SIRPA may behave similarly to CD14, xref which promotes the endosome/lysosome-mediated degradation of TLR4."
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"We then performed coimmunostaining and coimmunoprecipitation experiments to validate whether SIRPA physically interacts with TLR4."
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"Collectively, these results demonstrate that SIRPA inhibits TLR4 expression and directly interacts with TLR4."
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"31 In our study, we found that the expression of TLR4 was downregulated by SIRPA after pressure overload and that SIRPA can directly interact with TLR4."
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"43 In our study, we demonstrated that SIRPA physically interacted with TLR4; therefore, SIRPA may behave similarly to CD14, 42 which promotes the endosome and lysosome mediated degradation of TLR4."
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