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ATXN3 activates Neoplasm Metastasis. 11 / 11
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"ATXN3 promotes breast cancer metastasis in vitro and in vivo in a KLF4-dependent manner.In our experiment, we observed that KLF4 and ATXN3 interacted with each other through amino acids 220–240 on KLF[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In addition, the protein level of EIF5A2 was also significantly consistent with the protein level of ATXN3 in clinical ATC tissues, while the mRNA expression level of ATXN3 was not consistent with the[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Then, we demonstrated that ATXN3 can promote the proliferation and metastasis of ATC cells in vivo and in vitro."
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"We verified that ATXN3 stabilizes KLF4 through deubiquitination in breast cancer and promotes cancer metastasis."
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"ATXN3 could promote metastasis in MCF-7, MDA-MB-231, and 4 T1 by deubiquitinating KLF4 ( Zou et al., 2019 )."
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"ATXN3 promotes breast cancer metastasis by stabilizing KLF4 through deubiquitination [35]."
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"Herein, these results indicate that EIF5A2 is essential for ATXN3-mediated regulation of ATC cell proliferation.To further investigate whether ATXN3 mediates the metastasis of ATCs through EIF5A2, we [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"ATXN3 accelerated tumor metastasis via regulation of KLF4 stability in breast cancer cells and mice [147] ."
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"Our study showed that the overexpression of EIF5A2 significantly promoted the migration and invasion of SW1736 cells, and knockdown of ATXN3 reversed the enhanced metastasis induced by upregulation of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To further confirm the function of ATXN3 in vivo, xenograft experiments demonstrated that depletion of ATXN3 similarly inhibited tumor growth and lung metastasis of prostate cancer (Fig. 5J–L)."
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"Moreover, our results indicated that ATXN3 promotes ATC proliferation and metastasis in vitro."
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