IndraLab

Statements

CACNA1A inhibits ion channel. 7 / 7
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"It is concluded that electrical restitution in rat ventricular muscle is relatively little affected by recovery from voltage-dependent inactivation of ion channels, it is rather governed by transient changes in cytosolic Ca concentration possible via Ca-dependent inactivation of the L-type Ca current and activation of the Na/Ca exchange current."
8899061
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"However, the regulation of glucagon secretion is more complicated since it has been shown that exocytosis can as well be triggered by membrane depolarization via a voltage-dependent inactivation of ion channels involved in action potential generation ( xref )."
20978093
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"This behavior is notably different from the canonical voltage-dependent inactivation of ion channels, where channels enter an absorbing non-conductive inactive state [ xref ]."
25966688
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"We propose that glucose-induced closure of the K(ATP)-channels, via membrane depolarization, culminates in reduced electrical activity and glucagon secretion by voltage-dependent inactivation of the ion channels involved in action potential firing."
21824262
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"Structure/function studies from this laboratory have demonstrated that pH gating follows a particle-receptor mechanism, similar to the "ball-and-chain" model of voltage-dependent inactivation of ion channels."
9670915
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"Thus it is likely that other mechanisms, in addition to disrupted ionic gradients and voltage-dependent inactivation of ion channels, are involved in the prolonged suppression of synaptic activity."
22864185
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"Voltage-dependent inhibition of ligand-gated ion channels suggests binding of the inhibitory drug to a site within the channel or at the mouth of the channel."
11044725