IndraLab

Statements

TNF binds NOTCH1. 6 / 6
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"By linking Notch and TNFα it was shown that (1) Notch-1 mucosal expression differs in inflamed and non-inflamed mucosa and increases in response to anti-TNFα treatment; (2) Notch-1 function is regulated by TNFα inhibitors; (3) Notch-1 binds to TNFα; and (4) Notch-1 inhibition prevents anti-TNFα-induced T cell cycle arrest but not apoptosis."
22068169
sparser
"In parallel with our findings, Daniel et al. [43] reported that TNF-α inhibited Mfn2 expression in cells and that Notch1 could directly bind to TNF-α [44] , supporting positive regulation of Mfn2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
27387769
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"TNF promoted p52/RELB binding to NICD, which enhanced binding at the RBPjκ site within the Hes1 promoter."
24892805
sparser
"We also observed potential interacting pairs between EP_C1_LMP1 cells with activated Notch pathway and multiple cell types through NOTCH1-TNF and NOTCH2-JAG2, which have been related to radiation sensitivity xref and cancer stem-like side population cells xref in NPC (Supplementary Fig.  xref )."
33531485
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"The upregulation of constitutive nuclear factor NF-κB, as well as CD30, CD40, tumor necrosis factor (TNF)-α, and Notch1 interactions contributes to these processes ( xref )."
26498453
reach
"By linking Notch and TNFalpha it was shown that (1) Notch-1 mucosal expression differs in inflamed and non inflamed mucosa and increases in response to anti-TNFalpha treatment; (2) Notch-1 function is regulated by TNFalpha inhibitors; (3) Notch-1 binds to TNFalpha; and (4) Notch-1 inhibition prevents anti-TNFalpha-induced T cell cycle arrest but not apoptosis."
22068169