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USP8 decreases the amount of iron atom. 2 / 2

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"We also found that depletion of USP8 increased lipid ROS levels and ferrous iron levels, while decreased the GSH levels in LM3 and HepG2 cells (Fig. 5I–K)."

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"Consistently, knockout of USP8 decreased cystine uptake, GSH level, and increased ferrous iron level and lipid ROS (Figure 3J–M)."

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USP8 decreases the amount of iron atom. 2 / 2

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