IndraLab

Statements

OTUB1 activates localization. 5 / 5
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"One of the most interesting aspects of the study by Nakada et al. [55] is that depletion of OTUB1 rescues the 53BP1 localization and HR defects associated with loss of ATM activity."
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"Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization."
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"OTUB1 has been reported to enhance membrane localization and promote the activation of wild-type KRAS—but not KRAS mutants—by suppressing the enzymatic activity of E2 enzymes ubiquitin-conjugating enzyme 13 (UBC13) and ubiquitin-conjugating enzyme E2 D3 (UBE2D3), indicating that OTUB1 regulates wild-type KRAS in an indirect manner ."
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"For example, the phosphorylation of OTUB1 at Ser16 site leads to its nuclear localization, which is very important to repair DNA damage [ 31 ]."
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"As a result, OTUB1 increases RAS localization to the plasma membrane and the activation of the downstream MAPK pathway (Baietti et al., 2016)."
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