IndraLab

Statements

Alvespimycin inhibits CASP1. 3 / 3
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reach
"Administration of 17-DMAG in mouse model of ALD significantly downregulated NLRP3 inflammasome-mediated caspase-1 (CASP-1) activity and cytokine secretion, with reduction in ALD."
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reach
"Administration of 17-DMAG in mouse model of ALD significantly downregulated NLRP3 inflammasome mediated caspase-1 (CASP-1) activity and cytokine secretion, with reduction in ALD."
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reach
"Next to assess NLRP3 inflammasome mediated proteolytic cleavage of pro-CASP-1 to active CASP-1, we performed western blot analysis of BMDM cell lysates and found that 17-DMAG significantly diminished ATP/NLRP3 mediated cleavage of pro-CASP-1 to CASP-1 p10 fragment in BMDMs (Figure 4F)."
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