IndraLab

Statements

USP22 decreases the amount of AR. 4 / 5
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"USP22 Depletion Suppresses Ligand Dependent and Castration Resistant AR Expression and Activity."
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"Schrecengost et al XREF_BIBR previously showed that USP22 depletion dramatically downregulated androgen receptor protein levels and abolished androgen receptor activity in both androgen deprivation therapy and castration resistant prostate adenocarcinoma cells."
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"Conversely, depletion of USP22 dramatically down-regulates AR protein levels and abrogates basal and DHT stimulated AR activity in both ADT sensitive and CRPC cells."
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"In contrast, USP22 depletion reduced AR protein levels in the absence of androgen, and inhibited DHT induced AR expression, within in models of therapy sensitive disease (XREF_FIG, compare lanes 2, 4)."
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