IndraLab
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"It deubiquitinates and stabilizes mitochondrial respiratory chain complex I subunit NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2) to suppress apoptosis in pancreatic cancer cells, xref whereas its enzyme-independent stabilization of MDMX enhances phosphorylation of p53 at serine 46 (p53S46P), promoting the mitochondrial apoptosis pathway. xref This effect is mechanistically distinct from MDM2-mediated p53 degradation: rather than influencing p53 protein stability, OTUB1-MDMX interaction modulates p53 PTM and activity."