IndraLab

Statements


Nitric oxide increases the amount of USP5. 3 / 4
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"Local administration of NO may prevent neointimal hyperplasia by inhibiting isopeptidase T levels and activity in the vasculature, thereby inhibiting the 26S proteasome in VSMCs."

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"Nitric oxide may inhibit neointimal hyperplasia by decreasing isopeptidase T levels and activity in the vasculature."

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"NO caused a time dependent increase in S nitrosylated isopeptidase T levels in VSMCs, which was reversible with dithiothreitol, indicating that isopeptidase T undergoes reversible S nitrosylation on exposure to NO in vitro."