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USP2 inhibits apoptotic process. 12 / 13
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"USP2 knockout also induced apoptosis in these two MM cell lines (Fig. 5C and D)."
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"Moreover, USP2 silencing enhanced apoptosis after PUVA treatment in MyLa2000 suggesting that USP2 enhanced therapeutic resistance."
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"In addition, we observed that the ectopic of USP2 WT diminishes the apoptosis, whereas overexpression of catalytically mutated USP2 (C276A) causes apoptosis in ML362-plus-TRAIL-treated cells (Figure 6B)."
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"Here, we found that USP2 showed decreased expression in advanced CTCL compared with the early stage disease and blocked apoptosis in malignant p53 wt T-lymphocytes."
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"Finally, the knockdown of USP2 in Hut-78 cells did not increase apoptosis after PUVA, in contrast to what was observed in MyLa2000 with intact p53."
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"Pharmacological USP2 targeting suppresses ovarian cancer growth by potentiating apoptosis and ferroptosis."
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"Overexpression of survivin or USP2 significantly prevented apoptosis through cotreatment with ML364 and TRAIL, whereas a knockdown of USP2 increased sensitivity to TRAIL."
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"USP2 knockdown via siRNA inhibits actinomycin and TNF-α-induced apoptosis via c-FLIP upregulation in hepatocytes [27]."
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"USP2 reduces cell apoptosis via p53 signaling."
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"Stevenson, et al. showed that USP2 prevents cell apoptosis induced by stabilizing MDM2, in turn leading to p53 reduction XREF_BIBR, XREF_BIBR."
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"In vitro an artificial knockdown of USP2 inhibited actinomycin D/TNFalpha-induced hepatocyte apoptosis, which was associated with elevated levels of the anti-apoptotic protein c-Flip(L/S) and a concomitant decrease of cellular levels of the ubiquitinligase Itch, a negative regulator of c-Flip."
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"The knockdown of USP2 protects hepatocytes from TNF-induced apoptosis by interference with CFLAR signaling [18]."
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