IndraLab

Statements

BRAF activates USP5. 6 / 6
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"Furthermore, BRAF (a melanoma mutation gene) activation of USP5 can inhibit cell cycle checkpoint control and cell apoptosis by blocking p53 and FAS induction [ 40 ]."
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"Furthermore, BRAF (a melanoma mutation gene) activation of USP5 can inhibit cell cycle checkpoint control and cell apoptosis by blocking p53 and FAS induction [ 40 ]."
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"USP5 activation by BRAF can inhibit cell cycle checkpoint control and apoptosis through blockage of p53 and FAS induction, while its knockdown overcomes vemurafenib resistance and sensitizes BRAF and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Overall, our results demonstrate that BRAF activates Usp5 to suppress cell cycle checkpoint control and apoptosis by blocking p53 and FAS induction; all of which can be restored by small molecule mediated Usp5 inhibition."
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"Overall, our results demonstrate that BRAF activates Usp5 to suppress cell cycle checkpoint control and apoptosis by blocking p53 and FAS induction; all of which can be restored by small molecule-mediated Usp5 inhibition."
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"Usp5 was consistently suppressed, but not fully inhibited, by kinase inhibitor or BRAF knockdown."
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