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Histone inhibits RELA. 3 / 3
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"Similarly, demethylation of a histone lysine residue in the proximal p65 promoter H3K9 produces a reduced inhibition of p65 and acts synergistically with the H3K4 modification to produce increased inf[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
26079815
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"We previously reported that the epigenetic signature requires induction of NF-kappaB factor RelB, which directs histone H3K9 dimethylation, disrupts assembly of transcription activator NF-kappaB p65, and induces a sustained switch from the euchromatin to heterochromatin."
19158276
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"Based on these combined results, it appears that acetylation is required for maximal activity of p65, which is consistent with results showing that overexpression of CBP and p300 enhances the activation potential of p65, whereas overexpression of histone deacetylases (HDAC) represses p65 activity."
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