IndraLab

Statements

USP28 inhibits cell differentiation. 3 / 3
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"Knockdown of USP28 could induce the differentiation of CSCs while attenuate their self-renewal, which can be reversed by LSD1 expression."
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"In support of these findings, USP28 knockdown impaired the self-renewal capacity of cancer stem cells (CSCs) derived from MMTV-Wnt1 tumors and promoted their differentiation."
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"Let-7 is a tumor suppressor that also plays an essential role in the acceleration of cell differentiation [92, 93]; hence, we infer that USP28 may inhibit cell differentiation through its indirect function on let-7."
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