IndraLab

Statements

USP25 activates homologous recombination. 4 / 4
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"Cells overexpressing USP21 increased HR efficiency, and cells defective of USP21 showed a significant decrease in HR [33]."
| PMC
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"Notably, tumor associated SCNAs often result from non allelic homologous recombination events 49, consistent with our observation that USP21 positively regulates HR."
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"Consequently, USP21 depletion reduced the efficiency of HR, leading to increased DNA damage load and concomitant impairment of hepatocellular carcinoma (HCC) cell survival (Liu et al., 2017)."
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"Deactivation of USP21 reduces the HR activity and increases the DNA damage frequency [XREF_BIBR]."
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