IndraLab

Statements

USP7 activates FOXP3. 7 / 7
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"Knockdown of USP7 or DUB inhibitor induced the loss of Foxp3 protein in Tregs."
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"A prior study showed that USP7 modulates FOXP3, an essential transcriptional factor for Treg functioning [13]."
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"The compounds demonstrated a long-lasting inhibitory effect on murine Treg cells in vitro at 10 μM. USP7 inhibition downregulated both Foxp3 and its positive regulator Tip60."
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"For example, USP44 and USP7 appeared to promote FOXP3 function in regulating Th17- and Treg-cell differentiation (11, 12)."
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"USP7 directly regulates the stabilization of Foxp3, a crucial transcription factor of regulatory T (Treg) cells, resulting in an increased number and enhanced regulatory function of Treg cells in vivo (16)."
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"Control of ubiquitination of the FOXP3 protein by enhancing its acetylation (HDAC inhibition, p300 induction), inhibiting cytokine-induced Stub1 levels and enhancing USP7 expression, prevents FOXP3 degradation."
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"In addition, USP7 promotes Treg suppression by enhancing the multimerization of Tip60 and Foxp3 (153)."
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