IndraLab

Statements

USP7 activates FOXP3. 4 / 4
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"Knockdown of USP7 or DUB inhibitor induced the loss of Foxp3 protein in Tregs."
25175772
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"Control of ubiquitination of the FOXP3 protein by enhancing its acetylation (HDAC inhibition, p300 induction), inhibiting cytokine-induced Stub1 levels and enhancing USP7 expression, prevents FOXP3 degradation."
34224053
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"In addition, USP7 promotes Treg suppression by enhancing the multimerization of Tip60 and Foxp3 (153)."
31681337
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"A prior study showed that USP7 modulates FOXP3, an essential transcriptional factor for Treg functioning [13]."
33487632