IndraLab

Statements

USP4 inhibits Neoplasms. 4 / 4
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"In addition, Ye et al. suggested that USP4 had anti-cancer effect in breast cancer, and found that USP4 could inhibited the growth of tumors in a mouse tumor xenograft model45."
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"In contrast, knockdown of USP4 markedly inhibited gastric cancer cell growth, and suppressed the tumor growth of gastric cancer."
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"Consistently, USP4 silencing repressed tumor growth and metastasis in an ESCC nude mouse model in vivo."
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"Further research has demonstrated that USP4 suppresses tumor growth by interacting with RIP1, deubiquitinating K63-linked RIP1 and inhibiting NF-κB activation, resulting in tumor suppressor effects (58)."
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