IndraLab

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MIF inhibits COPS5. 21 / 21
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"We conclude that MIF may act broadly to negatively regulate Jab1 controlled pathways and that the MIF-Jab1 interaction may provide a molecular basis for key activities of MIF."
11089976
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"When MIF and JAB1 are bound to each other in various intracellular sites, MIF inhibits the positive regulatory effects of JAB1 on the activity of AP-1."
28366190
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"MIF inhibits Csn5 resulting in the downregulation of JNK signaling pathway [14]."
37935315
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"MIF inhibits JAB1 activity."
14502271
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"Jab1/CSN5 controls MIF-mediated activation of PI3K/AKT signaling by inhibition of MIF secretion and its autocrine prosurvival activities ( Lue et al., 2007 )."
30468907
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"Bernhagen 's group first identified that MIF negatively regulates the activity of cytosolic Jab1 on both steady-state and stimulus induced AP-1-dependent transcription."
33324425
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"Given that AP-1 is associated with activation of pro inflammatory responses in numerous immune cell types, an anti-inflammatory and immunosuppressive role for MIF might be expected when intracellular MIF concentrations are at sufficient levels to functionally inhibit Jab1 and CSN5."
33324425
sparser
"MIF inhibits Csn5 resulting in the downregulation of JNK signaling pathway [ xref ]."
37935315
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"Meanwhile, MIF could interact with Jun-activation domain-binding protein 1 (JAB1) in the cytosol, antagonize JAB1-controlled pathways, and modulate cellular redox homeostasis (Kleemann et al., 2000; Lue et al., 2007)."
31365744
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"In turn, MIF negatively regulates Jab1/CSN5 as MIF can specifically interact with Jab1/CSN5 and inhibit Jab1/CSN5- enhanced activator protein 1 (AP-1) activity and c-Jun amino-terminal kinase (JNK) ac[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30468907
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"Jab1 has been implicated in modulating MIF signaling and conversely, it is also known that MIF abrogates Jab1 mediated degradation of p27 Kip1 [25]."
17560571
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"In contrast, MIF also negatively regulates Jab1 and COPS5 by specifically interacting with Jab1 and COPS5 and inhibiting the activity of activator protein 1 (AP-1) and c-Jun amino terminal kinase (JNK)."
29535627
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"Subsequent functional studies showed that MIF can antagonize several JAB1 and CSN5 based cellular effects."
11932196
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"MIF and JAB1 are co-localized in the cytoplasm and MIF inhibits the positive regulatory effects of JAB1 on the activity of JNK and AP1 (Fig. 4a)."
14502271
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"Intracellular MIF sequesters CSN5 to block AP-1 transcriptional factor activity [XREF_BIBR]."
26352431
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"Consequently, MIF blocks JAB1-mediated rescue of fibroblasts from growth arrest."
22959722
sparser
"Because JAB1 is involved in the regulation of AP1-dependent transcription and the cell cycle, and MIF inactivates JAB1 by binding to it, the cytosolic pool of MIF appears to be engaged in an additional regulatory circle distinct from the MAPK/ERK pathway."
28208600
eidos
"MIF inhibits JAB1 activity ."
14502271
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"MIF would thereby inhibit Jab1 enhanced AP-1 transcriptional activity [XREF_BIBR]."
19413900
sparser
"MIF inhibits Jab1- and stimulus-enhanced AP-1 activity, but does not interfere with the induction of the transcription factor NFkappaB."
11089976
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"For example, MIF activates mitogen activated protein kinase signaling pathways in NIH/3T3 fibroblasts 13 and endogenous MIF inhibits Jab1 activity and antagonizes Jab1 dependent cell-cycle regulation."
11875000