IndraLab

Statements

HMGB1 binds USP50. 6 / 6
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"In order to investigate the involvement of the USP50-HMGB1 axis in DGR-induced gastric tumorigenesis, gastric cancer cell lines SNU216 and HGC27 were co-cultured with conditioned media (CM) from macrophages exposed to TDCA (TDCA-CM)."
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"USP50-HMGB1 axis promotes tumor proliferation and invasion through PI3K/AKT and MAPK/ERK pathways."
38469295
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"To confirm that USP50-HMGB1 axis-driven gastric tumorigenesis is mediated by the PI3K/AKT and MAPK/ERK pathways, herein we utilized ERK1/2 inhibitor SCH772984 and AKT inhibitor MK-2206."
38469295
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"In summary, the USP50-HMGB1 axis facilitates gastric tumorigenesis through the PI3K/AKT and MAPK/ERK pathways."
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"These results suggest that the USP50-HMGB1 axis may contribute to gastric tumorigenesis."
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"USP50-HMGB1 axis contributes to DGR-induced gastric tumorigenesis."
38469295