IndraLab

Statements

Mutated KCNH2 activates Kr. 3 / 3
| 3
reach
"Precise genetic modification of the KCNH2 mutation increased the I Kr current conducted by the hERG channel and normalized the APD [XREF_BIBR]."
33255277
reach
"Loss-of-function (LOF) KCNH2 mutations decrease I Kr in type 2 LQTS (LQT2) XREF_BIBR, XREF_BIBR, XREF_BIBR."
27761161
reach
"As hERG underpins the rapid delayed rectifier channel current (I Kr) XREF_BIBR, the N588K ' gain-of-function ' hERG mutation is anticipated to increase greatly the contribution of I Kr to cardiac repolarization in SQT1 patients, thereby accounting for QT interval abbreviation XREF_BIBR, XREF_BIBR - XREF_BIBR."
22194679