IndraLab

Statements

BAP1 activates homologous recombination. 3 / 3
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"In the nucleus, BAP1 modulates the transcriptional regulation of several gene programs and promotes DNA repair by facilitating homologous recombination ."
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"BAP1 deubiquitylates Ub-H2AK119 at sites of DNA damage, and the loss of BAP1 has been shown to impair homologous recombination (HR) repair (10)."
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"We reasoned that if BAP1 interacts with BARD1 to modulate homologous recombination and possibly other cellular pathways, germline BARD1 mutations might also predispose to mesothelioma, and that these patients might have a better prognosis, similar to carriers of germline BAP1 mutations."
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