IndraLab

Statements

Acetylated TP53 decreases the amount of TP53. 4 / 4
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"Pre-treatment of PFT-α followed by 4-(Benzyloxy)phenol treatment decreased the expression of p53 as well as acetylated p53 ( Fig. 6 A and B), suggesting the specific role of 4-(Benzyloxy)phenol in enh[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"An increase in p53 acetylation via SIRT2 inhibition reduces cytoplasmic p53 levels, thus blocking its inhibitory effect on autophagy [XREF_BIBR], suggesting that SIRT2 inhibition may present a key pharmacological strategy in restoring autophagy function."
| PMC
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"Linker histone H1.2 has been shown to suppress p53-dependent transcription through the modulation of chromatin remodeling, but acetylation of p53 destabilizes its interaction with H1.2 via conformatio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"This increasing level of p53 acetylation with HDAC inhibitors prevents p53 degradation thereby maintaining a tight regulation of functional p53 levels by acetylation and deacetylation."
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