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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Acetylated TP53 decreases the amount of TP53. 2 / 2

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"An increase in p53 acetylation via SIRT2 inhibition reduces cytoplasmic p53 levels, thus blocking its inhibitory effect on autophagy [XREF_BIBR], suggesting that SIRT2 inhibition may present a key pharmacological strategy in restoring autophagy function."

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"This increasing level of p53 acetylation with HDAC inhibitors prevents p53 degradation thereby maintaining a tight regulation of functional p53 levels by acetylation and deacetylation."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...