IndraLab

Statements

OTUD5 leads to the phosphorylation of TRIM28 on S824. 5 / 5
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"We find that OTUD5 promotes ATM-mediated phosphorylation of KAP1 S824 in response to telomere deprotection, as well as in response to genome-wide, ionizing radiation (IR)-induced DNA damage."
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"We identified that the OTU family deubiquitinase (DUB) OTUD5 promotes KAP1 S824 phosphorylation by facilitating ATM activation, through stabilization of the ubiquitin ligase UBR5 that is required for DNA damage-induced ATM activity."
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"We identified that the OTU family deubiquitinase (DUB) OTUD5 promotes KAP1 S824 phosphorylation by facilitating ATM activation, through stabilization of the ubiquitin ligase UBR5 that is required for DNA damage-induced ATM activity."
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"Next, we assessed the potential functional involvement of UBR5 in OTUD5-promoted KAP1 S824 phosphorylation, by depleting OTUD5, UBR5, or both in U2OS cells."
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"Loss of OTUD5 impairs KAP1 S824 phosphorylation, which suppresses end-joining mediated DNA repair at deprotected telomeres and at DNA breaks in heterochromatin."
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