IndraLab

Statements

COPS6 binds FBXW7. 3 / 3
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"The binding of COP9 signalosome subunit 6 (CSN6) to FBXW7β inhibits the degradation of fatty acid synthase (FASN), promoting lipogenic CRC and tumor progression (Wei et al., 2023)."
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"CSN6’s association with Fbxw7 facilitates its degradation."
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"First, we found that CSN6 associated with Myc, Fbxw7 and Cullin-1 in U2OS cells in vivo (XREF_FIG), suggesting that CSN6 interacts with SCF complex and may regulate it to stabilize Myc."
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