IndraLab

Statements

Atorvastatin inhibits NLRP3. 14 / 14
| 14
reach
"In the present study, we demonstrated that atorvastatin decreased the vulnerability of advanced atherosclerotic plaques, and inhibited the inflammatory response and the activation of NLRP3 inflammasomes, by inducing autophagy in ApoE -/- mice."
29773990
reach
"Later, this group found that NEXN-AS1 and NEXN can be significantly induced by the cholesterol-lowering agent atorvastatin, which decreased expression of pyroptosis-related proteins, including NLRP3, caspase-1, GSDMD, IL-1β, and IL-18, in human vascular ECs (HVECs).83 Knockdown of NEXN-AS1 or RNA interference of NEXN abrogates the inhibitory effect of atorvastatin on pyroptosis, indicating the critical regulatory role of NEXN-AS1/NEXN in transferring the anti-pyroptotic signal from atorvastatin to the NLRP3 inflammasome.83 Myocardial I/R injury and myocardial infarction."
34458007
reach
"Atorvastatin Upregulated Autophagy Through the mTOR Pathway and Inhibited the Activation of NLRP3 Inflammasome in RAW264.7 Cells."
29773990
reach
"Atorvastatin Significantly Inhibited the Activation of NLRP3 Inflammasomes."
29773990
reach
"In vivo experiments confirmed that atorvastatin could inhibit the activation of NLRP3 inflammasomes and subsequent inflammation in atherosclerotic plaques."
29773990
reach
"Combined Administration of Metformin and Atorvastatin Inhibited NLRP3 Inflammasome in H9C2 Cells Exposed to Palmitate via Toll Like Receptor 4/NF-kappaB Signaling Pathway."
33718370
reach
"Atorvastatin could also inhibit NLRP3 inflammasome activation and inflammatory cytokines, such as IL-1beta, TNF-alpha, and IL-18 secretion in vivo."
29773990
reach
"Combined Treatment With Metformin and Atorvastatin Inhibited Activation of NLRP3 Inflammasome in Heart Tissues of db/db Mice."
33718370
reach
"As shown in Figures XREF_FIG - XREF_FIG, western blotting and immunostaining showed that atorvastatin significantly reduced the abundance of NLRP3 in ox-LDL-induced macrophages."
29773990
reach
"Atorvastatin may suppress the activation of NLRP3 inflammasome at certain steps of the NLRP3 cascade."
32929357
reach
"In order to indicate whether metformin and atorvastatin could inhibit NLRP3 inflammasome activation, the expression levels of NLRP3 and its downstream molecules (caspase-1 and IL-1beta) were detected by Western blot assay."
33718370
reach
"As shown in Figures XREF_FIG, atorvastatin significantly reduced the abundance of NLRP3 inflammasomes (p < 0.05)."
29773990
reach
"In the present study, we found that atorvastatin suppressed NLRP3 inflammasome activation in vulnerable atherosclerotic plaques and in activated macrophages stimulated by ox-LDL."
29773990
reach
"Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling."
34494933