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Atorvastatin inhibits NLRP3. 26 / 26
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"Atorvastatin also significantly inhibits oxidative stress and the TLR4/NF-κB and NLRP3 inflammasome pathways, ultimately improving CaOx crystal deposition and crystal-induced damage in HK-2 cells and renal tissue of rats (88)."
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"As shown in Fig. 4 D and E, atorvastatin-induced inhibition of NLRP3, caspase-1, GSDMD, IL-1β, and IL-18 expression was markedly abolished by knockdown of NEXN , indicating that NEXN antisense RNA lev[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Later, this group found that NEXN-AS1 and NEXN can be significantly induced by the cholesterol-lowering agent atorvastatin, which decreased expression of pyroptosis-related proteins, including NLRP3, caspase-1, GSDMD, IL-1β, and IL-18, in human vascular ECs (HVECs).83 Knockdown of NEXN-AS1 or RNA interference of NEXN abrogates the inhibitory effect of atorvastatin on pyroptosis, indicating the critical regulatory role of NEXN-AS1/NEXN in transferring the anti-pyroptotic signal from atorvastatin to the NLRP3 inflammasome.83 Myocardial I/R injury and myocardial infarction."
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"Modern research shows that statins, as analogues of 3-hydroxy-3-methylglutaryl coenzyme A inhibitor (HMG-CoA) and typically utilized for their cholesterol-lowering ability, also have pleiotropic effects, including immunomodulatory and anti-inflammatory abilities.Wu et al. [170] revealed that atorvastatin, the most researched member of the class, inhibits the NLRP3 inflammasome and the molecules involved in pyroptosis, such as caspase-1 and IL-1 β, by increasing the production of NEXN-antisense RNA1 (AS1) lncRNA and its related gene NEXN [170,171]."
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"In the present study, we found that atorvastatin suppressed NLRP3 inflammasome activation in vulnerable atherosclerotic plaques and in activated macrophages stimulated by ox-LDL."
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"For example, atorvastatin reduces inflammation by blocking the NLRP3 inflammasome pathway, and long-term use can alleviate liver inflammation, steatosis, and hepatocellular damage [201]."
| PMC
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"Atorvastatin suppresses the NLRP3 inflammasome pathway, reducing pro-inflammatory cytokines IL-1β and IL-18, and attenuates NASH progression by decreasing TNF-α levels (141)."
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"Atorvastatin may suppress the activation of NLRP3 inflammasome at certain steps of the NLRP3 cascade."
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"In another study, Chen et al. found that atorvastatin inhibited activity of both the NLRP3 and AIM2 inflammasomes in a mouse model of EBI, attenuating pyroptotic neuronal death ."
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"In an in vitro study, Chen et al. [116] reported that atorvastatin significantly inhibited TNF-α-induced activation of the NLRP3 inflammasome and reduced the activity of MMP-3 and MMP-13 by enhancing autophagy."
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"In this study we have also demonstrated that atorvastatin and PQQ per se and supplementation of PQQ with ATS could downregulate the hepatic gene and protein expression of NLRP3 and caspase1 in HFFD ra[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Atorvastatin inhibited TNF-α induced matrix degradation in rat nucleus pulposus cells by suppressing NLRP3 inflammasome activity and inducing autophagy through NF-κB signaling."
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"Combined Administration of Metformin and Atorvastatin Inhibited NLRP3 Inflammasome in H9C2 Cells Exposed to Palmitate via Toll Like Receptor 4/NF-kappaB Signaling Pathway."
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"In order to indicate whether metformin and atorvastatin could inhibit NLRP3 inflammasome activation, the expression levels of NLRP3 and its downstream molecules (caspase-1 and IL-1beta) were detected by Western blot assay."
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"Our previous study revealed that atorvastatin promoted autophagy and decreased NLRP3 activity in TNF-α-treated NP cells [22]."
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"Combined Treatment With Metformin and Atorvastatin Inhibited Activation of NLRP3 Inflammasome in Heart Tissues of db/db Mice."
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"Sun et al. also elucidated that by regulating TLR4/NF-κB axis and NLRP3 inflammasome, atorvastatin could reduce renal inflammatory response induced by calcium oxalate stones [11]."
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"Atorvastatin could also inhibit NLRP3 inflammasome activation and inflammatory cytokines, such as IL-1beta, TNF-alpha, and IL-18 secretion in vivo."
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"Atorvastatin Significantly Inhibited the Activation of NLRP3 Inflammasomes."
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"As shown in Figures XREF_FIG, atorvastatin significantly reduced the abundance of NLRP3 inflammasomes (p < 0.05)."
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"Atorvastatin has been found to inhibit the activation of the NOD-like receptor family, NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome pathway induced by cholesterol crystals, thereby reducing the expression of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, which are implicated in NAFLD progression [85]."
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"On the other hand, the downregulation of NLRP3 by atorvastatin, and rosuvastatin is also stated [60,70,71]."
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"Atorvastatin Upregulated Autophagy Through the mTOR Pathway and Inhibited the Activation of NLRP3 Inflammasome in RAW264.7 Cells."
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"In vivo experiments confirmed that atorvastatin could inhibit the activation of NLRP3 inflammasomes and subsequent inflammation in atherosclerotic plaques."
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"As shown in Figures XREF_FIG - XREF_FIG, western blotting and immunostaining showed that atorvastatin significantly reduced the abundance of NLRP3 in ox-LDL-induced macrophages."
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"In the present study, we demonstrated that atorvastatin decreased the vulnerability of advanced atherosclerotic plaques, and inhibited the inflammatory response and the activation of NLRP3 inflammasomes, by inducing autophagy in ApoE -/- mice."
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