IndraLab

Statements

Buprenorphine inhibits KCNH2. 3 / 3
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"Methadone is the opiod most tightly associated with QTc prolongation; with much lesser potency buprenorphine and oxycodone can block HERG channels and depress the IKr current in vitro.Antineoplastic chemotherapy like anthracyclines, alkylating drugs, alkilants and cisplatin are associated with electrocardiographic alterations including prolongation of QT and emesis of different grades."
20210727
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"Methadone, buprenorphine and many structurally diverse drugs can block the hERG XREF_BIBR, XREF_BIBR resulting in a prolonged QTc interval XREF_BIBR."
20407978
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"In vitro studies of many opioids, including buprenorphine, have shown that these drugs block the inward potassium rectifier activity of potassium voltage-gated channel subfamily H member 2 (also known as hERG1), which potentially leads to corrected QT interval (QTc) prolongation and ventricular dysrhythmias, including torsades de pointes."
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