IndraLab

Statements

KCNH2 inhibits autophagy. 4 / 4
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"Hence, silencing hERG1 triggers autophagy but, at difference with hERG1 blockade, does not impair the autophagy flux."
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"Nonetheless, hERG1 knockdown per se induces autophagy, as was evidenced by an increase of LC3-II as well as of AVOs-positive cells."
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"Pharmacological blockage of the potassium channel KCNH2 by macrolide antibiotics triggers autophagy by inhibiting AKT in acute leukemia cells [49]."
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"Hence, blocking hERG1 triggers autophagy and blocks the autophagic flux, similarly to MAs."
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