IndraLab

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VEGFA binds VEGFC and NRP2. 2 / 2
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"Interestingly, in breast cancer, HH–GLI signaling was triggered in an autocrine manner by stimulation of the VEGF receptor neuropilin-2 (NRP2), xref whose expression in NSCLCs has been linked to unfavorable outcomes. xref , xref , xref In its role as a VEGF receptor, NRP2 specifically binds both VEGFA and VEGFC, xref and VEGF/NRP signaling impacts the biology of stem-like tumor cells in various types of cancer. xref , xref , xref We wondered whether oncogenic NRP2/ERK signaling might be the upstream cause of the noncanonical GLI1 activity in LAC cells."
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"NRP2 specifically binds VEGF-A and VEGF-C, although the biological relevance of these interactions in human endothelial cells is poorly understood."
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