IndraLab

Statements

BAP1 inhibits BCL2L11. 3 / 3
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"The tumour was histopathologically atypical because of the presence of confluent pleomorphism, solid sheets of cells and grouped mitotic figures : these features were consistent with a melanocytic neoplasm with intermediate morphology (' BAP1 inactivated melanocytoma '; BIM) between a BAP1 inactivated melanocytic naevus and a BAP1 inactivated melanoma."
33107024
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"Here we report the clinical features, histopathologic findings, and chromosomal copy number data of 19 BAP1-inactivated melanocytomas (BIMs) and compare their features to those of five BAP1-inactivated melanomas."
39976080
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"None of the stained tumors in our study exhibited the concurrent BAP1 loss and BRAF V600E positivity that are characteristic of adult BIM, suggesting that this is a low-frequency mutation among banal tumors in the pediatric population."
39076037