IndraLab

Statements

COPS6 inhibits Ubiquitin. 3 / 3
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"Indeed, we revealed that CSN6 reduces the stability of UBR5 by regulating the ubiquitin mediated degradation of UBR5, furtherly stabilizing CDK9 expression, suggesting that UBR5 may be a downstream factor of CSN6 in melanoma cells."
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"Taken together, these results indicate that EGF signaling elevated CSN6 and COP1 to cause down regulation of FOXO4 regardless of its PKB/Akt‐mediated phosphorylation status.2.2 CSN6 Enhances Ubiquitin-Mediated Degradation of FOXO4 through K48 Link."
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"2.1 EGF Signal and CSN6/COP1 Enhance Ubiquitin-Mediated Degradation of FOXO4."
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