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COPS6 inhibits Ubiquitin. 8 / 8
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"Study in colorectal cancer has found that up-regulation of CSN6 by EGF decreases SCF ubiquitin ligase substrate receptor β-transduction repeat-containing protein (β-TrCP) by promoting its autocatalyti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We have shown that CSN6 promotes ubiquitin-dependent degradation of TRIM21, and it is then possible that CSN6 can regulate FASN stability through TRIM21 as well."
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"Taken together, these results indicate that EGF signaling elevated CSN6 and COP1 to cause down regulation of FOXO4 regardless of its PKB/Akt‐mediated phosphorylation status.2.2 CSN6 Enhances Ubiquitin-Mediated Degradation of FOXO4 through K48 Link."
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"These data suggested that CSN6 attenuates ubiquitin-mediated degradation of FASN, thereby stabilizing FASN protein."
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"Furthermore, CSN6 has been found to decrease β-TrCP by promoting its autocatalytic degradation, thereby stabilizing SCF ubiquitin ligase substrate in colorectal cancer cells [22] ."
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"2.1 EGF Signal and CSN6/COP1 Enhance Ubiquitin-Mediated Degradation of FOXO4."
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"Indeed, we revealed that CSN6 reduces the stability of UBR5 by regulating the ubiquitin mediated degradation of UBR5, furtherly stabilizing CDK9 expression, suggesting that UBR5 may be a downstream factor of CSN6 in melanoma cells."
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"These observations demonstrated that CSN6 might promote the 20S proteasomal ubiquitin-independent degradation of p16."
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