IndraLab

Statements

OSM activates OSMR. 24 / 24
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"Mechanistically, OSM activates the heterodimeric receptor complex gp130:OSMR [ xref ], resulting in the activation of JAK/STAT [ xref ] and MAPK signaling pathways."
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"OSMR was reported to form a heterodimerized receptor with glycoprotein 130 and could be activated specifically by its ligand OSM."
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"By contrast, OSM treatment stimulated robust interaction of OSMR with EGFR in the control astrocytes (XREF_FIG)."
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"Importantly, OSM induces the dimerization of OSMR with another receptor partner IL6ST."
34380633
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"To investigate whether B14 and B21 monoclonal antibodies (mAbs) inhibit OSM-induced dimerization of OSMR with IL6ST, we immunoprecipitated OSMR-IL6ST heterodimer complex cross-linked after treating with anti-OSMR antibody or control IgG."
34380633
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"The oncostatin m receptor (osmr) is part of receptor complexes for oncostatin m and interleukin-31."
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"Thus, YAP and TEAD1 upregulate OSM in CMs, and OSM upregulates YAP and TEAD1, as well as OSMR through YAP and TEAD1, in CMs, suggesting that YAP, TEAD1, and OSM and OSMR form an amplification loop to enhance OSM function and promote de-differentiation of CMs."
30582455
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"LIFR and gp130 can be activated by either LIF or OSM, but OSMR and gp130 is activated only by OSM [18]."
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"gp130 and LIFR can be activated by LIF or OSM, but gp130 and OSMR is activated by OSM only."
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"For this purpose, human GBM cell lines LN18 and LN229 showing basal levels of OSMR (XREF_SUPPLEMENTARY B) were treated with OSM (50 ng/ml) for 12 hours and tested for a panel of markers."
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"For example, ERK1/2, PI3K, and STAT1/3 can be activated by OSM binding the LIFR or OSMR, but only signaling through the OSMR can activate STAT5, p38, JNK, and possibly PKC-δ and STAT622.OSM has been identified as a potential therapeutic target for treatment of inflammatory diseases."
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"When coupled with the observation that OSM and OSMR are significantly elevated in PDAC, and OSMR is induced by OSM, the unique signaling emanating from the OSMR justifies a more thorough analysis of OSM and the signaling cascades described here."
28053127
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"On the molecular level this usage of OSM from different species results in the stimulation of different receptor complexes : human OSM exclusively binds to the type I gp130 and LIFR system in mouse cells; murine OSM, however, exclusively activates the type II gp130 and OSMR system."
22937020
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"In mice, oncostatin M receptor (OSMR) and leukemia inhibitory factor receptor (LIFR) are selectively activated by the respective cognate ligands while OSM activates both the OSMR and LIFR in humans, which prevents efficient translation of mouse data into potential clinical applications."
35008777
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"Together, these findings suggest a potential model of bidirectional myeloid cell-astrocyte crosstalk in which (1) Gal-9 produced by astrocytes upregulates Osm via Dectin-1 in myeloid cells and (2) myeloid cell-derived Osm triggers beneficial OsmR signaling in astrocytes."
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"Because OSM is required to trigger the interaction of OSMR with EGFR in astrocytes that do not express oncogenic EGFRvIII, we assessed the influence of OSM on EGFR and STAT3 signaling in these cells."
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"The mRNA levels of both OSMR and HGF showed a gradual increase when MSCs were treated with increasing concentrations of OSM from 0.5 to 5 ng/ml (XREF_FIG, XREF_FIG)."
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"Moreover, OSMR is induced by OSM ligand, suggesting that a positive feedback loop is engaged to promote greater OSMR/JAK/STAT3 activation and maintain the induced mesenchymal and CSC cell state."
28053127
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"gp130 and OSMR is activated only by OSM, but gp130 and LIFR can be activated by either LIF, OSM or both."
21617854
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"In a mouse model, OSMR overexpressing SCC cells treated with OSM showed significant increases in lung colonisation."
27351213
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"For this purpose, human GBM cell lines LN18 and LN229 showing basal levels of OSMR were treated with OSM (50 ng/ml) for 12 hours and tested for a panel of markers."
25748242
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"Indeed, OSM reduced neurosphere cell proliferation and increased p-STAT3, OSMR and GFAP."
| PMC
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"OSM can signal though both the LIFR (OSMR type I in humans) and OSMR (OSMR type II in humans) in humans and rats, while in mice, only signaling via the OSMR is possible."
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"OSM also upregulates SOCS3 (a STAT3 target gene) and additional mesenchymal markers, including VIM (encodes Vimentin), CDH2 (encodes N-cadherin), OSMR (encodes OSM receptor subunit β; OSMRβ), STAT3, and the EMT-TFs SNAI1 (encodes Snail), TWIST1, ZEB1, and ZEB2 (Fig. 1h)."
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