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USP15 activates VGLL4. 3 / 3
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"Subsequent experiments were designed to establish that USP15 enhances the stability of VGLL4."

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"USP15 depletion led to the destabilization of VGLL4 protein ( Fig. 3 h–k), whereas USP15 overexpression increased the stability of endogenous VGLL4 protein ( Fig. 3 l-o)."

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"In contrast, overexpression of USP15 in TNBC cells resulted in a significant upregulation of VGLL4 ( Fig. 3 d–f)."