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ERAP1 binds USP47. 4 / 4
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"The interaction of the positive HH regulator ERAP1 with USP47 induces the degradation of βTrCP, thus protecting GLIs from βTrCP-dependent degradation and stimulating HH activity [ xref ]."
32531973
reach
"We demonstrate that ERAP1 binds the deubiquitylase enzyme USP47, displaces the USP47 associated betaTrCP, the substrate-receptor subunit of the SCF betaTrCP ubiquitin ligase, and promotes betaTrCP degradation."
31341163
sparser
"ERAP1-USP47 binding disrupts the USP47-β-TrCP binding and subsequent ubiquitination and proteasomal degradation of β-TrCP, leading to increases in the levels of the GLI1 and GLI2 proteins in the Hedgehog (Hh) pathway."
37686524
reach
"Bufalieri et al. identified endoplasmic reticulum aminopeptidase 1 (ERAP1) as a new player in the Hedgehog pathway, and ERAP1 binds to USP47, displacing β-TrCP from SCF , a ubiquitin ligase, therefore promoting β-TrCP degradation ."
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