IndraLab

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KCNA3 activates cell population proliferation. 36 / 39
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"While Kv1.3 promotes cell proliferation, the lack of selective pharmacological tools makes research with Kv1.5 difficult [4,14,15] ."
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"Thus, pharmacological blockade of Kv1.3 inhibits the proliferation and cytokine production of the pathogenic T EM cells while sparing other lymphocyte subpopulations [59] ."
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"Another Kv1.3 blocker, PAP-1, dose-dependently inhibited proliferation and suppressed IL-2 and IFN-γ production in in vitro studies performed with lesional mononuclear cells or T cells derived from the skin and joints of psoriatic patients [127]."
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"Compared with control group, gene silencing of Kv1.3 and KCa3.1 respectively inhibited the proliferation of T cells."
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"To determine whether overexpression of Kv1.3 further induced proliferation of VSMCs in culture, we then examined proliferation in cells infected with Lv-Kv1.3."
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"Here, we show that Kv1.3 promotes the proliferation of preadipocytes through the control of mitochondrial dynamics."
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"Our results demonstrate that Kv1.3 promotes preadipocyte proliferation and differentiation by controlling mitochondrial membrane potential and mitochondrial dynamics at the G1 phase of the cell cycle."
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"46 In good agreement with these results, an in vitro study overexpressing different Kv channels does not report an impact on OL differentiation, but on OPC proliferation: Kv1.3 and Kv1.4 overexpressio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Studies performed in heterologous expression systems suggest that while the presence of Kv1.3 promotes cell proliferation, the overexpression of Kv1.6 attenuates cell growth [21] ."
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"Plasma membrane Kv1.3 mediates cellular activation and proliferation, whereas mitochondrial Kv1.3 participates in cell survival and apoptosis."
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"As we know, T cell activation and proliferation are initially regulated by Kv1.3 on the cell membrane."
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"Using human A549 lung adenocarcinoma model, researchers found that either blockade or suppression of Kv1.3 could significantly inhibit cell proliferation and reduced tumor volume by 75% in vivo (35)."
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"The markedly reduced peaks of the gray-shaded histogram relative to the control light-gray line in Fig. 2 A qualitatively show that the Kv1.3 K + channel blocker anuroctoxin (Antx) at 10 × K d concent[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Some studies demonstrate that proliferation is attenuated by inhibitors of the three proteins: charybdotoxin, clotrimazole or TRAM-34 for KCa3.1 [27,29,30] ; charybdotoxin or margatoxin for Kv1.3 [16,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Consistently, our data show that Kv1.3 blockade inhibits HASMC proliferation both under control and uremic–serum treatment."
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"It implies that inhibition of Kv1.3 channel by curcumin induced a regulation of inflammatory cytokines and prevented the proliferation of T cells."
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"While plasma membrane Kv1.3 in general seems to promote proliferation, mitochondrial Kv1.3 participates in cell death [10,11,12,13,14,15,16,17,18]."
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"However, LY2784544 did mitigate the increased proliferation induced by the overexpression of Kv1.3 in VSMCs."
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"We found that ox-LDL stimulation upregulated the expression levels of Kv1.3 and induced proliferation in VSMCs."
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"In contrast, Kv1.3 overexpression led to increased proliferation and phosphorylation levels of JAK2 and STAT3."
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"Toxins isolated from venomous animals such as margatoxin and stichodactyla helianthus (ShK) are selective blockers for Kv1.3 but many other K + channel inhibitors are nonspecific although they reduce [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The specific Kv1.3 channel inhibitor clofazimine can inhibit cancer cell proliferation and induce cancer cell apoptosis through the mitochondrial pathway (9)."
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"When cells were exposed to human control serum, Kv1.3 inhibition significantly decreased proliferation at all time points tested (Figure 6B and C)."
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"A recent study in HEK293 cells showed that Kv1.3 promoted proliferation by driving the generation of reactive oxygen (ROX) through protein-protein interactions between its C-terminal phosphorylation s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Moreover, several studies have indicated that inhibition of Kv1.3 can prevent smooth muscle proliferation and migration in vitro as well as in the context of in vivo vascular injury models [114,115], thus prompting investigations into Kv1.3 inhibitors as therapeutics to prevent restenosis."
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"Kir4.1 and Kv1.3 overexpression promote OPCs proliferation and myelination regeneration, but Kv1.6 inhibits it (Song et al., 2018; Liu et al., 2021)."
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"Alteration of Kv1.3 expression during transition from contractile to proliferating phenotype has been previously described.21 27 32 Kv1.3 can modulate cell proliferation by several alternative mechanisms, including (1) controlling membrane potential and thus the driving force for Ca entry; (2) acting as a voltage sensor that transduces membrane potential into biochemical signals36; (3) altering the channelosome balance relatively to Kv1.5 expression."
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"In contrast, the proliferation of quiescent rat T-cells was only slightly inhibited by specific Kv1.3 blockers, which is a special property of rat T-cells (see above the dissimilarity with human T-cel[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The specific Kv1.3 channel inhibitor clofazimine, as a membrane-permeable small molecule organic compound, can inhibit cancer cell proliferation and induce cancer cell apoptosis through the mitochondrial pathway (9)."
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"The inhibition of the K channel, named Kv1.3, inhibits T-cell activation, calcium signaling, cytokine production, and cell proliferation (44)."
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"According to the expectations the proliferation of Kv1.3 high IKCa1 low T EM cells was completely and persistently inhibited by Shk toxin, a potent blocker of Kv1.3."
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"We also have to point out that Kv1.3 (and possibly other Shaker channels as well) can apparently also promote proliferation independently of its ion-conducting properties (see, e.g., [38,39])."
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"Selective blockage of Kv1.3 channels was experimentally demonstrated to suppress T EM cell proliferation and thus provided an attractive new way for treating T-cell-mediated autoimmune diseases [4,9,2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In vivo evidence for the involvement of Kv1.3 in tumor growth has been obtained in an A549 human lung adenocarcinoma model: margatoxin (Mgtx), a selective blocker of Kv1.3 (IC 50 2 nM) or short hairpi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, it has been shown that Kv1.3 (KCNA3) and Kv3.1 (KCNC1) blockade increases neural progenitor cell proliferation [XREF_BIBR]; likewise, induction of H + flux induces regeneration of a complex appendage [XREF_BIBR] and blockade of gap junction mediated signals results in the formation of a complete, properly patterned head in a planarian tail blastema [XREF_BIBR]."
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"Blocking Kv1.3 increased p-Akt and prevented IL-17-induced loss of cell viability and proliferation inhibition."
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