IndraLab

Statements

Parthenolide inhibits NFKBIA. 5 / 5
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"Although the oleate activated AKT, IkappaBalpha and ERK were inhibited by LY294002, parthenolide and U0126, respectively, only LY294002 and parthenolide significantly inhibited the oleate induced PTX3 expression."
28489600
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"Pretreatment of cells with the inhibitor of Ikappa-Balpha degradation parthenolide prevented the CNIs elicited inflammatory response, suggesting regulation by NF-kappaB."
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"Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation."
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"Parthenolide, a sesquiterpene lactone, directly binds to and inhibits IκBα and also blocks the binding of NF-κB to DNA [ xref ] ( xref )."
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"Parthenolide has been shown to inhibit NF-kappaB activity by preventing the breakdown of IkappaB-alpha and IkappaB-beta, both of which are responsible for the sequestration of NF-kappaB to the cytopla[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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