IndraLab

Statements

Fumaric acid inhibits NLRP3. 4 / 4
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"Previously NLRP3 has been shown to be inhibited through covalent modification by several reactive metabolites including diroximel fumarate , a fumarate derivative, as well as itaconate at which modifies at C548 of murine NLRP3 which inhibits NLRP3 interactions with NEK7 ."
38659753
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"DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1β release."
35137954
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"Consequently, the fumarate analog dimethylfumarate blocked cell death and lactate dehrdrogenase (LDH) release in response NLRP3 activation, but also in response to NLRC4 and AIM2 stimulation [ 60 ]."
36371361
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"Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages."
35137954