IndraLab

Statements

Fumaric acid inhibits NLRP3. 3 / 3
| 3
reach
"DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1β release."
35137954
reach
"Fumaric acid esters prevent the NLRP3 inflammasome mediated and ATP triggered pyroptosis of differentiated THP-1 cells."
26096886
reach
"Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages."
35137954