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UCHL1 inhibits Ubiquitin. 8 / 10
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"Furthermore, free monomeric ubiquitin is reduced by 20-30% in the brains of UCH-L1 deficient mice [XREF_BIBR - XREF_BIBR]."
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"UCHL1 interacted with CAV1 and inhibited its ubiquitin-mediated degradation pathway."
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"Pre-treatment with the UCHL1 inhibitor attenuated HIF1α stabilization by low oxygen, consistent with UCHL1 preventing ubiquitin-mediated degradation of HIF1α (Figure 2D and Supplementary Figure S1)."
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"A higher reduction in ubiquitin carboxy-terminal-hydrolase L1 (PGP9.5) mRNA correlated with a better response based on Asthma Quality of Life Questionnaire (AQLQ)."
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"By recognizing and cutting the ubiquitin chains connected with EGFR, UCHL1 reduced the degradation of EGFR through the ubiquitin-proteasome system, thus continuously activating EGFR, Akt and ERK signalling pathways, leading to myocardial hypertrophy (Ref."
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"A previous study has shown that inhibition of UCH-L1 hydrolase activity induces the aggregation of ubiquitin-conjugated proteins and thus enhances cell death in primary neurons [23] ."
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"Since UCHL1 has a high affinity for ubiquitin, it has been suggested that UCHL1 may serve to sequester ubiquitin and prevent its degradation."
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"In addition, western blotting of proteins from primary cells derived from the spinal ligament tissues of wild-type mice treated with the ubiquitin ligase inhibitor (HLI 373), treated with recombinant UCHL1, or transfected with miR-340 showed that expression of CXCL7 was not completely suppressed by miR-340 transfection."
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