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BAP1 activates radioresistance. 4 / 4
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eidos
"In conclusion , we found that BAP1 can deubiquitinate H2Aub and induces radioresistance in HNSCC cells via modulation of HR ."
29113987
eidos
"We observed that 2 Gy x 5 days of radiation treatment had minimal effect on control tumors ( Fig. 5 ) but led to a significant decrease in growth of BAP1-KD tumors ( Fig. 5 ; P < 0.05 ) , suggesting that BAP1 mediated radioresistance in this xenograft model ."
29113987
eidos
"Thus , BAP1 seems to regulate H2Aub in HNSCC cells and may be a mechanism by which BAP1 induces radioresistance via facilitating DNA repair ."
29113987
eidos
"BAP1 was found to mediate radioresistance in an in vivo xenograft model and HNSCC cell lines via the deubiquitination of H2A and modulation of HR ."
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