IndraLab

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USP28 deubiquitinates KDM1A. 5 / 6
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"USP28 functions as a bona fide deubiquitinating enzyme for LSD1, as it interacts with and stabilizes LSD1 through the process of deubiquitination."
40034124
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"The results above suggest that USP28 may stimulate EMT via its deubiquitination of LSD1 and Snail and then suppress EMT-related molecules.In addition to the molecules involved in EMT, other molecules, such as Lin28A, which is a crucial regulator of invasiveness, can also accelerate metastasis [84]."
36879346
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"Therefore, USP28 can maintain Notch signaling, through which cell differentiation is inhibited.Moreover, LSD1, which can be deubiquitinated by USP28, has the capacity to regulate pluripotency markers such as octamer-binding transcription factor 4 (Oct4) and SRY-related HMG box-containing 2 (SOX2) and the differentiation gene p21 [9, 83, 91]."
36879346
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"We found that WT-USP28, but not CI-USP28, specifically removed LSD1 ubiquitination (XREF_FIG), indicating that USP28 directly deubiquitinated LSD1."
24075993
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"USP7 and USP28 inhibited LSD1 ubiquitination and stabilized LSD1 protein level [XREF_BIBR, XREF_BIBR]."
29142505